The Nuclear Pore Complex as a Transcription Regulator

Michael Chas Sumner, Jason Brickner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal loci physically interact with nuclear pore proteins (Nups), and interactions with Nups can promote transcriptional repression, transcriptional activation, and transcriptional poising. Interaction with the NPC also affects the spatial arrangement of genes, interchromosomal clustering, and folding of topologically associated domains. Thus, the NPC is a spatial organizer of the genome and regulator of genome function.

Original languageEnglish (US)
Article numbera039438
JournalCold Spring Harbor Perspectives in Biology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2022

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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