The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus

Yayoi Ikeda, Xunrong Luo, Rula Abbud, John H. Nilson, Keith L. Parker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

342 Scopus citations

Abstract

The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Müllerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.

Original languageEnglish (US)
Pages (from-to)478-486
Number of pages9
JournalMolecular Endocrinology
Volume9
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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