The nuclear transport machinery in Caenorhabditis elegans: A central role in morphogenesis

Stephen A Adam*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Our full understanding of the various roles for the nuclear transport machinery has come from a variety of model organisms including yeast, nematodes, fruit flies and vertebrates. Using the nematode Caenorhabditis elegans, it has been shown that the karyopherin family of nuclear transporters and the components of the Ran cycle have roles not only in nuclear protein transport, but also in mitotic spindle formation and regulation, and in nuclear envelope assembly. These studies have also demonstrated a role for nuclear transport factors in cellular differentiation and development, particularly for the formation of germ cells. This review highlights the small number of studies in C. elegans that have been critical to our understanding of this important cellular process.

Original languageEnglish (US)
Pages (from-to)576-581
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume20
Issue number5
DOIs
StatePublished - Jan 1 2009

Keywords

  • C. elegans
  • Importin
  • Karyopherin
  • Nuclear transport
  • Nucleoporin
  • Ran

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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