The ontogeny of partial seizures in infants and young children

Douglas R. Nordli*, Maxine M. Kuroda, Lawrence J. Hirsch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Purpose: To describe the clinical manifestations of partial seizures in the pediatric population as a function of age. Methods: Using the database of the pediatric epilepsy monitoring unit (Children's Hospital of New York), clinical and EEG characteristics of partial seizures were distributed by age groups 0-2, 2-6, and 6+ years for 123 patients who had at least one such seizure with a clear EEG correlate during their admission. X2 tests for trend were used to examine clinical and EEG features as a function of age. Results: The frequency of aura, limb automatisms, dystonic posturing, secondary generalization, and unresponsiveness increased with age, whereas asymmetric clonus and symmetric tonic posturing decreased with age. There were no clear changes in the types of EEG ictal patterns observed with age; however, partial seizures emanating from the anterior regions of the brain tended to increase with age, whereas those from the posterior regions tended to decrease with age. Conclusions: Important differences exist in the clinical expression of seizures between young children and adults. These findings will contribute to a better understanding of ictal ontogeny that will promote more accurate classification of seizures and of the epilepsies in young patients. Such efforts can be used to identify young patients for focal epilepsy surgery and to select appropriate anticonvulsive medications.

Original languageEnglish (US)
Pages (from-to)986-990
Number of pages5
Issue number8
StatePublished - 2001


  • Age-related features
  • Epilepsy
  • Infants
  • Seizures

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'The ontogeny of partial seizures in infants and young children'. Together they form a unique fingerprint.

Cite this