The oocyte

Allison R. Grover, Barbara Fegley, Timothy V. Duncan, Francesca E. Duncan

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The mammalian oocyte has tremendous potential energy because it is capable of giving rise to an entirely new generation upon fertilization. In addition to providing the embryo with half its DNA content, the oocyte also endows the early embryo with the majority of its cellular volume because the sperm volume is orders of magnitude smaller. The cellular volume of the oocyte contains critical maternal products that are essential for supporting the developmental events of meiosis, fertilization, and early embryo development. In this article, we review the cellular architecture of the mammalian oocyte, key biological processes that dictate the developmental potential of the oocyte, and physiological and extrinsic factors that can impact oocyte quality.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
Number of pages8
ISBN (Electronic)9780128151457
StatePublished - Jan 1 2018


  • Aging
  • Bisphenol a
  • Cortical granules
  • Cytoplasmic lattice
  • Egg
  • Fertilization
  • Germinal vesicle
  • Meiosis
  • Obesity
  • Oncofertility
  • Oocyte
  • Organelles
  • Polycystic ovarian syndrome
  • Transzonal projection
  • Zona pellucida

ASJC Scopus subject areas

  • General Medicine


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