The optimal timing of hepatitis C therapy in transplant eligible patients with child b and c cirrhosis: A cost-effectiveness analysis

Elliot B. Tapper*, Michael S. Hughes, Maria Buti, Jean Francois Dufour, Steve Flamm, Saima Firdoos, Michael P. Curry, Nezam H. Afdhal

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Background. Ledipasvir (LDV)/sofosbuvir (SOF) has demonstrated high efficacy, safety, and tolerability in hepatitis C virus (HCV)-infected patients. There is limited data, however, regarding the optimal timing of therapy in the context of possible liver transplantation (LT).Methods.We compared the cost-effectiveness of 12 weeks of HCV therapy before or after LTor nontreatment using a decision analytical microsimulation state-transition model for a simulated cohort of 10 000 patients with HCV Genotype 1 or 4 with Child B or C cirrhosis. All model parameters regarding the efficacy of therapy, adverse events and the effect of therapy on changes in model for end-stage liver disease (MELD) scores were derived from the SOLAR-1 and 2 trials. The simulations were repeated with 10 000 samples from the parameter distributions. The primary outcome was cost (2014 US dollars) per quality adjusted life year. Results. Treatment before LTyielded more quality-adjusted life year for less money than treatment after LT or nontreatment. Treatment before LT was cost-effective in 100% of samples at a willingness-to-pay threshold of US 100 000 in the base-case and when the analysis was restricted to Child B alone, Child C, orMELD > 15. Treatment before transplant was not cost-effective when MELD was 6-10. In sensitivity analyses, the MELD after which treatment before transplant was cost-effective was 13 and the maximum cost of LDV/SOF therapy at which treatment before LT is cost-effective is US 177 381. Conclusions. From a societal perspective, HCV therapy using LDV/SOF with ribavirin before LT is the most cost-effective strategy for patients with decompensated cirrhosis and MELD score greater than 13.

Original languageEnglish (US)
Pages (from-to)987-995
Number of pages9
JournalTransplantation
Volume101
Issue number5
DOIs
StatePublished - May 2017

ASJC Scopus subject areas

  • Transplantation

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