The Pathophysiologic Basis for Epidemiologic Trends in Gastroesophageal Reflux Disease

John E. Pandolfino*, Monika A. Kwiatek, Peter J. Kahrilas

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Gastroesophageal reflux disease (GERD) is defined by either subjective complaints indicative of problematic gastroesophageal reflux or objective complications directly attributable to reflux. Studies focused on GERD-related symptoms suggest a worldwide increase in prevalence of approximately 4% per year. Epidemiologic data indicate that possible contributing factors include increasing longevity, rising obesity rates, greater consumption of medications affecting esophageal function, and potentially changing prevalence rates of Helicobacter pylori infection. This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis.

Original languageEnglish (US)
Pages (from-to)827-843
Number of pages17
JournalGastroenterology Clinics of North America
Issue number4
StatePublished - Dec 2008


  • GERD
  • Helicobacter Pylori
  • Longevity
  • Obesity

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'The Pathophysiologic Basis for Epidemiologic Trends in Gastroesophageal Reflux Disease'. Together they form a unique fingerprint.

Cite this