The Pathophysiologic Basis for Epidemiologic Trends in Gastroesophageal Reflux Disease

John Erik Pandolfino*, Monika A. Kwiatek, Peter J Kahrilas

*Corresponding author for this work

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Gastroesophageal reflux disease (GERD) is defined by either subjective complaints indicative of problematic gastroesophageal reflux or objective complications directly attributable to reflux. Studies focused on GERD-related symptoms suggest a worldwide increase in prevalence of approximately 4% per year. Epidemiologic data indicate that possible contributing factors include increasing longevity, rising obesity rates, greater consumption of medications affecting esophageal function, and potentially changing prevalence rates of Helicobacter pylori infection. This article explores the interplay between pathophysiology and epidemiology by focusing on these risk factors and their potential effect on GERD pathogenesis.

Original languageEnglish (US)
Pages (from-to)827-843
Number of pages17
JournalGastroenterology Clinics of North America
Volume37
Issue number4
DOIs
Publication statusPublished - Dec 1 2008

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Keywords

  • GERD
  • Helicobacter Pylori
  • Longevity
  • Obesity

ASJC Scopus subject areas

  • Gastroenterology

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