The pedunclopontine nucleus and Parkinson's disease

Cecilia Tubert, Daniel Galtieri, D. James Surmeier*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


In the last decade, scientific and clinical interest in the pedunculopontine nucleus (PPN) has grown dramatically. This growth is largely a consequence of experimental work demonstrating its connection to the control of gait and of clinical work implicating PPN pathology in levodopa-insensitive gait symptoms of Parkinson's disease (PD). In addition, the development of optogenetic and chemogenetic approaches has made experimental analysis of PPN circuitry and function more tractable. In this brief review, recent findings in the field linking PPN to the basal ganglia and PD are summarized; in addition, an attempt is made to identify key gaps in our understanding and challenges this field faces in moving forward.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalNeurobiology of Disease
StatePublished - Aug 2019

ASJC Scopus subject areas

  • Neurology


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