The perinucleolar compartment associates with malignancy

Yiping Wen, Chen Wang, Sui Huang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The perinucleolar compartment (PNC) is a unique nuclear substructure, forming predominantly in cancer cells both in vitro and in vivo. PNC prevalence (percentage of cells containing at least one PNC) has been found to positively correlate with disease progression in several cancers (breast, ovarian, and colon). While there is a clear association between PNCs and cancer, the molecular function of the PNC remains unclear. Here we summarize the current understanding of the association of PNCs with cancer and its possible functions in cancer cells.

Original languageEnglish (US)
Pages (from-to)369-376
Number of pages8
JournalFrontiers in Biology
Issue number4
StatePublished - Aug 2013


  • PNC
  • cancer
  • gene expression regulation
  • nuclear substructure
  • structure and function

ASJC Scopus subject areas

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics


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