The pharmacologic basis of diuretic therapy in the newborn

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The regulation of electrolytes and water in the newborn are presented in this article, concentrating on those features that differ in the immature and mature human and those aspects that are important to understanding diuretic effects. The pathophysiology of water and sodium balance in various disorders serves to present the indications for diuretic therapy. The pharmacodynamics of individual diuretic agents is presented, and the pharmacokinetics and toxicity of the commonly used agents is discussed.

Original languageEnglish (US)
Pages (from-to)951-964
Number of pages14
JournalClinics in Perinatology
Issue number4
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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