The PI3′ kinase pathway in interferon signaling

Surinder Kaur, Shahab Uddin, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations


Interferons (IFNs) are pleiotropic cytokines with important immunomodulatory, antitumor, antiviral, and growth inhibitory properties. Consistent with the multiplicity of their effects, the IFNs activate several cellular cascades after they bind to their receptors. Although the Jak-Stat pathway is the most studied pathway, it appears that additional signaling cascades play roles in IFN signaling. The phosphatidylinositol 3′-kinase (PI3′ K) pathway has emerged as one of the critical players in IFN signal transduction and is the focus of this review. This pathway is activated distinctively from the Stat pathway but plays important roles in the regulation of IFN-dependent gene transcription and initiation of mRNA translation.

Original languageEnglish (US)
Pages (from-to)780-787
Number of pages8
JournalJournal of Interferon and Cytokine Research
Issue number12
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology


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