The pinwheel experiment re-revisited

Alexandre Sambelashvili, Igor R. Efimov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Virtual electrode induced phase singularity hypothesis explains the origin of cardiac arrhythmias caused by artificial electrical induction of rotors, i.e. vortex-like self-sustained sources of activity. This mechanism is thought to underlie both stimulus-induced arrhythmias and shock defibrillation therapy. In this paper, we extend this hypothesis to three dimensions using the bidomain model of cardiac tissue. We predict that virtual electrode polarization can produce three topologically distinct types of rotors anchored to: (1) transmural I-shaped scroll wave filaments; (2) near-surface U-shaped scroll wave filaments; and (3) intramural O-shaped scroll wave filaments.

Original languageEnglish (US)
Pages (from-to)147-153
Number of pages7
JournalJournal of Theoretical Biology
Issue number2
StatePublished - 2002

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics


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