The pinwheel experiment re-revisited

Alexandre Sambelashvili; Igor R. Efimov

doi:10.1006/jtbi.2001.2456

The pinwheel experiment re-revisited

Alexandre Sambelashvili, Igor R. Efimov^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Virtual electrode induced phase singularity hypothesis explains the origin of cardiac arrhythmias caused by artificial electrical induction of rotors, i.e. vortex-like self-sustained sources of activity. This mechanism is thought to underlie both stimulus-induced arrhythmias and shock defibrillation therapy. In this paper, we extend this hypothesis to three dimensions using the bidomain model of cardiac tissue. We predict that virtual electrode polarization can produce three topologically distinct types of rotors anchored to: (1) transmural I-shaped scroll wave filaments; (2) near-surface U-shaped scroll wave filaments; and (3) intramural O-shaped scroll wave filaments.

Original language	English (US)
Pages (from-to)	147-153
Number of pages	7
Journal	Journal of Theoretical Biology
Volume	214
Issue number	2
DOIs	https://doi.org/10.1006/jtbi.2001.2456
State	Published - 2002

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.1006/jtbi.2001.2456

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title = "The pinwheel experiment re-revisited",

abstract = "Virtual electrode induced phase singularity hypothesis explains the origin of cardiac arrhythmias caused by artificial electrical induction of rotors, i.e. vortex-like self-sustained sources of activity. This mechanism is thought to underlie both stimulus-induced arrhythmias and shock defibrillation therapy. In this paper, we extend this hypothesis to three dimensions using the bidomain model of cardiac tissue. We predict that virtual electrode polarization can produce three topologically distinct types of rotors anchored to: (1) transmural I-shaped scroll wave filaments; (2) near-surface U-shaped scroll wave filaments; and (3) intramural O-shaped scroll wave filaments.",

author = "Alexandre Sambelashvili and Efimov, {Igor R.}",

note = "Funding Information: We thank Professors Bradley Roth, Natalia Trayanova, and Arthur Winfree for stimulating discussions, which led to this manuscript. This research was supported by grants from NIH, the Whitaker Foundation and the Elmer L. Lindseth endowment.",

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The pinwheel experiment re-revisited

Abstract

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