The poliovirus sensitivity (PVS) gene is on chromosome 19q12→q13.2

Teepu Siddique*, Ross McKinney, Wu Yen Hung, Richard J. Bartlett, Gail Bruns, Thuluvancheri K. Mohandas, Hans Hilger Ropers, Catherine Wilfert, Allen D. Roses

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Sensitivity to nonmodified poliovirus infection is an autosomal dominant trait, specific to primates. The gene for poliovirus sensitivity (PVS) is encoded on human chromosome 19. In order to sublocalize the PVS gene, we infected rodent-human hybrid cell lines that divide human chromosome 19 into four regions with poliovirus 1 and/or 3. When infected, these hybrid cell lines showed the typical cytopathic effect of poliovirus infection only if they contained 19q12→q13.2 as the smallest region of overlap. Appropriate negative and positive controls were used. PVS may be of relevance to myotonic dystrophy (DM) and the inherited motor neuron diseases: to DM because it localizes to the same region of chromosome 19 and to the inherited motor neuron diseases because it encodes a cell-surface receptor expressed on motor neurons.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalGenomics
Volume3
Issue number2
DOIs
StatePublished - Aug 1988

ASJC Scopus subject areas

  • Genetics

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