The polycystic ovary syndrome: Pathogenesis and treatment

R. Barnes, R. L. Rosenfield

Research output: Contribution to journalReview articlepeer-review

129 Scopus citations


Purpose: To propose a theory for the pathogenesis of the polycystic ovary syndrome that explains the endocrinologic abnormalities of the syndrome and provides a rational approach to therapy. Data Identification: An English-language literature search using MEDLINE (1975 to 1988) and extensive bibliographic reviews of identified articles. Study Selection: We reviewed the literature and selected 169 articles considered most relevant for the definition of the endocrinologic abnormalities, elucidation of pathogenic mechanism, or delineation of therapeutic interventions. Data Extraction: The authors independently assessed study quality and data concerning endocrinologic abnormalities, pathogenic mechanism, and therapy of the polycystic ovary syndrome. Results of Data Synthesis: The polycystic ovary syndrome may be best defined as functional, gonadotropin-dependent ovarian hyperandrogenism. The polycystic ovary syndrome results when a primary defect increases one of three variables: the ratio of the serum concentrations of luteinizing hormone to follicle stimulating hormone, the ratio of the intraovarian concentrations of androgen to estrogen, or follicular atresia. An increase in one of these variables can then induce successive abnormalities in one or more of the remaining two variables in a to-and-fro manner. Conclusions: Evidence suggest that several causes exist, each of which can produce the clinical syndrome by a to-and-fro interaction among pathogenic mechanisms. Treatment objectives for the syndrome include amelioration of hirsutism, induction of ovulation, and weight reduction.

Original languageEnglish (US)
Pages (from-to)386-399
Number of pages14
JournalAnnals of internal medicine
Issue number5
StatePublished - 1989

ASJC Scopus subject areas

  • Internal Medicine

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