The potential use of mechanism-based enzyme inactivators in medicine

Richard B Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations
Original languageEnglish (US)
Pages (from-to)73-90
Number of pages18
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume2
Issue number2
DOIs
StatePublished - Jan 1 1988

Keywords

  • Alanine racemase
  • Arginine decarboxylase
  • Aromatase
  • D-amino acid aminotransferase
  • Dihydrofolate reductase
  • Dihydroorotate dehydrogenase DNA polymerase I
  • Dopamine βhydroxylase
  • Histidine decarboxylase
  • L-aromatic amino acid decarboxylase
  • Mechanism-based enzyme inactivator
  • Monoamine oxidase
  • Ornithine decarboxylase
  • S-adenosylhomocysteine hydrolase
  • Serine proteases
  • Testosterone 5αreductase
  • Thymidylate synthetase
  • Xanthine oxidase
  • βlactamase
  • γaminobutyric acid aminotransferase

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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