The presence of a pituitary tumor in patients with prostate cancer is not a contraindication for leuprolide therapy

Angela Babbo, George T. Kalapurakal, Benjamin P Liu, Sanija Bajramovic, James P Chandler, John Garnett, John A Kalapurakal

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

PURPOSE: Gonadotropin analogs like leuprolide play an important role in the management of prostate cancer. Pituitary apoplexy has been reported after leuprolide therapy. This report examines whether the presence of a pituitary tumor is a contraindication for leuprolide therapy in patients with prostate cancer.

MATERIALS AND METHODS: Two patients with prostate cancer and pituitary tumors were treated with leuprolide and radiation therapy. The first patient with a previously unknown pituitary adenoma had a leuprolide injection for prostate gland downsizing prior to brachytherapy. The second patient with a known pituitary microadenoma had a biochemical recurrence and was treated with leuprolide and radiation therapy.

RESULTS: The first patient developed symptoms of apoplexy a few hours after the leuprolide injection. He underwent a transsphenoidal resection of the sellar mass with complete neurologic recovery. The second patient did not have any adverse events after leuprolide with follow-up MRI scans showing no growth of the microadenomas.

CONCLUSION: The presence of a pituitary tumor is not a contraindication for leuprolide therapy. While patients with a macroadenoma should have surgery first, those with a microadenoma may be considered for leuprolide therapy after careful evaluation by a multidisciplinary team.

Original languageEnglish (US)
Pages (from-to)1775-1778
Number of pages4
JournalInternational Urology and Nephrology
Volume46
Issue number9
DOIs
StatePublished - Sep 1 2014

ASJC Scopus subject areas

  • Nephrology
  • Urology

Fingerprint Dive into the research topics of 'The presence of a pituitary tumor in patients with prostate cancer is not a contraindication for leuprolide therapy'. Together they form a unique fingerprint.

Cite this