The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas

Hiroaki Kabashima; Masahiro Yoneda; Kengo Nagata; Takao Hirofuji; Yoshihisa Ishihara; Megumi Yamashita; Katsumasa Maeda

doi:10.1006/cyto.2001.0947

The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas

Hiroaki Kabashima, Masahiro Yoneda^*, Kengo Nagata, Takao Hirofuji, Yoshihisa Ishihara, Megumi Yamashita, Katsumasa Maeda

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.

Original language	English (US)
Pages (from-to)	62-66
Number of pages	5
Journal	Cytokine
Volume	16
Issue number	2
DOIs	https://doi.org/10.1006/cyto.2001.0947
State	Published - 2001

Funding

This work was in part supported by a Grants-in Aid for Scientific Research 13672189 from the Ministry of Education, Science, Sports and Culture of Japan.

Keywords

Chemokine
Chemokine receptor
Human periapical granuloma

ASJC Scopus subject areas

Molecular Biology
Hematology
Biochemistry
Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/cyto.2001.0947

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title = "The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas",

abstract = "The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.",

keywords = "Chemokine, Chemokine receptor, Human periapical granuloma",

author = "Hiroaki Kabashima and Masahiro Yoneda and Kengo Nagata and Takao Hirofuji and Yoshihisa Ishihara and Megumi Yamashita and Katsumasa Maeda",

note = "Funding Information: This work was in part supported by a Grants-in Aid for Scientific Research 13672189 from the Ministry of Education, Science, Sports and Culture of Japan.",

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doi = "10.1006/cyto.2001.0947",

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AU - Kabashima, Hiroaki

AU - Yoneda, Masahiro

AU - Nagata, Kengo

AU - Hirofuji, Takao

AU - Ishihara, Yoshihisa

AU - Yamashita, Megumi

AU - Maeda, Katsumasa

N1 - Funding Information: This work was in part supported by a Grants-in Aid for Scientific Research 13672189 from the Ministry of Education, Science, Sports and Culture of Japan.

PY - 2001

Y1 - 2001

N2 - The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.

AB - The infiltration of leukocytes into inflammation sites such as observed in human periapical granulomas is considered to be mediated by chemotactic factors. In this study, we examined the presence of chemokine- and chemokine receptor-positive cells in samples obtained from human subjects by means of immunohistochemical methods. Macrophage chemotactic protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1α, MIP-1β and IFN-inducible protein 10 (IP-10)-producing cells were present in periapical granulomas. In addition, chemokine receptor CCR3-, CCR5-, and CXCR3-positive cells were also present. In contrast, no factor expression was observed in clinically healthy periodontal ligament, serving as a negative control. Our findings suggest that these chemokines are responsible for modulating the process of disease, such as human apical periodontitis.

KW - Chemokine

KW - Chemokine receptor

KW - Human periapical granuloma

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The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP-1, MIP-1α, MIP-1β, IP-10)-positive cells in human periapical granulomas

Abstract

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Keywords

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UN SDGs

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