The pressure and volume dependence of the rate of wash-out in the bovine Eye

Mark Johnson; Anthia Chen; David L. Epstein; Roger D. Kamm

doi:10.3109/02713689108996343

The pressure and volume dependence of the rate of wash-out in the bovine Eye

Mark Johnson^*, Anthia Chen, David L. Epstein, Roger D. Kamm

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The rate of increase of outflow facility (the wash-out rate) was measured in bovine eyes at 6 and 15 mm Hg. The time-rate-of-change of facility was less at 6 mm Hg (0.20: Δfacility/hour) than at 15 mm Hg (0.44). However, when the data was analyzed as a function of volume passing through the outflow system, the volume-rate-of-change of facility was the same at 6 (0.35: Δfacility/ml) and 15 mm Hg (0.34). This was consistent with the hypothesis of macromolecules "washing-out" of the aqueous outflow system, if these macromolecules were saturable in the perfusate.

Original language	English (US)
Pages (from-to)	373-375
Number of pages	3
Journal	Current eye research
Volume	10
Issue number	4
DOIs	https://doi.org/10.3109/02713689108996343
State	Published - 1991

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Access to Document

10.3109/02713689108996343

Cite this

@article{74ec6d10e342420eaafbf8694b6ea006,

title = "The pressure and volume dependence of the rate of wash-out in the bovine Eye",

abstract = "The rate of increase of outflow facility (the wash-out rate) was measured in bovine eyes at 6 and 15 mm Hg. The time-rate-of-change of facility was less at 6 mm Hg (0.20: Δfacility/hour) than at 15 mm Hg (0.44). However, when the data was analyzed as a function of volume passing through the outflow system, the volume-rate-of-change of facility was the same at 6 (0.35: Δfacility/ml) and 15 mm Hg (0.34). This was consistent with the hypothesis of macromolecules {"}washing-out{"} of the aqueous outflow system, if these macromolecules were saturable in the perfusate.",

author = "Mark Johnson and Anthia Chen and Epstein, {David L.} and Kamm, {Roger D.}",

note = "Funding Information: ACKNOWLEDGEMENTS This study was supported by NIH grants EY05503 and EY01894 and a grant from National Glaucoma Research, a program of the American Health Assistance Foundation.",

year = "1991",

doi = "10.3109/02713689108996343",

language = "English (US)",

volume = "10",

pages = "373--375",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Informa Healthcare",

number = "4",

}

TY - JOUR

T1 - The pressure and volume dependence of the rate of wash-out in the bovine Eye

AU - Johnson, Mark

AU - Chen, Anthia

AU - Epstein, David L.

AU - Kamm, Roger D.

N1 - Funding Information: ACKNOWLEDGEMENTS This study was supported by NIH grants EY05503 and EY01894 and a grant from National Glaucoma Research, a program of the American Health Assistance Foundation.

PY - 1991

Y1 - 1991

N2 - The rate of increase of outflow facility (the wash-out rate) was measured in bovine eyes at 6 and 15 mm Hg. The time-rate-of-change of facility was less at 6 mm Hg (0.20: Δfacility/hour) than at 15 mm Hg (0.44). However, when the data was analyzed as a function of volume passing through the outflow system, the volume-rate-of-change of facility was the same at 6 (0.35: Δfacility/ml) and 15 mm Hg (0.34). This was consistent with the hypothesis of macromolecules "washing-out" of the aqueous outflow system, if these macromolecules were saturable in the perfusate.

AB - The rate of increase of outflow facility (the wash-out rate) was measured in bovine eyes at 6 and 15 mm Hg. The time-rate-of-change of facility was less at 6 mm Hg (0.20: Δfacility/hour) than at 15 mm Hg (0.44). However, when the data was analyzed as a function of volume passing through the outflow system, the volume-rate-of-change of facility was the same at 6 (0.35: Δfacility/ml) and 15 mm Hg (0.34). This was consistent with the hypothesis of macromolecules "washing-out" of the aqueous outflow system, if these macromolecules were saturable in the perfusate.

UR - http://www.scopus.com/inward/record.url?scp=0025903436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025903436&partnerID=8YFLogxK

U2 - 10.3109/02713689108996343

DO - 10.3109/02713689108996343

M3 - Article

C2 - 2070641

AN - SCOPUS:0025903436

SN - 0271-3683

VL - 10

SP - 373

EP - 375

JO - Current Eye Research

JF - Current Eye Research

IS - 4

ER -

The pressure and volume dependence of the rate of wash-out in the bovine Eye

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this