TY - JOUR
T1 - The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
AU - Lee, Yvonne C.
AU - Raychaudhuri, Soumya
AU - Cui, Jing
AU - De Vivo, Immaculata
AU - Ding, Bo
AU - Alfredsson, Lars
AU - Padyukov, Leonid
AU - Costenbader, Karen H.
AU - Seielstad, Mark
AU - Graham, Robert R.
AU - Klareskog, Lars
AU - Gregersen, Peter K.
AU - Plenge, Robert M.
AU - Karlson, Elizabeth W.
PY - 2009/5
Y1 - 2009/5
N2 - Objective. Previous studies have demonstrated that the PRL -1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility. Methods. We examined the association between PRL -1149 G/T and RA risk in 4 separate study populations, consisting of a total of 3,405 RA cases and 4,111 controls of self-reported white European ancestry. Samples were genotyped using 1 of 3 genotyping platforms, and strict quality control metrics were applied. We tested for association using a 2-tailed Cochran-Mantel-Haenszel additive, fixed-effects model. Results. In the individual populations, odds ratios (ORs) for an association between PRL -1149 T and RA risk ranged from 0.80 to 0.97. In a joint meta-analysis across all 4 populations, the OR for an association between PRL -1149 T and RA risk was 0.90 (95% confidence interval 0.84-0.96, P = 0.001). Conclusion. Our findings indicate a possible association between the PRL -1149 T allele and decreased RA risk. The effect size is small but similar to ORs for other genetic polymorphisms associated with complex traits, including RA.
AB - Objective. Previous studies have demonstrated that the PRL -1149 T (minor) allele decreases prolactin expression and may be associated with autoimmune disease. The aim of this study was to determine the role of the PRL -1149 G/T polymorphism (rs1341239) in rheumatoid arthritis (RA) susceptibility. Methods. We examined the association between PRL -1149 G/T and RA risk in 4 separate study populations, consisting of a total of 3,405 RA cases and 4,111 controls of self-reported white European ancestry. Samples were genotyped using 1 of 3 genotyping platforms, and strict quality control metrics were applied. We tested for association using a 2-tailed Cochran-Mantel-Haenszel additive, fixed-effects model. Results. In the individual populations, odds ratios (ORs) for an association between PRL -1149 T and RA risk ranged from 0.80 to 0.97. In a joint meta-analysis across all 4 populations, the OR for an association between PRL -1149 T and RA risk was 0.90 (95% confidence interval 0.84-0.96, P = 0.001). Conclusion. Our findings indicate a possible association between the PRL -1149 T allele and decreased RA risk. The effect size is small but similar to ORs for other genetic polymorphisms associated with complex traits, including RA.
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U2 - 10.1002/art.24468
DO - 10.1002/art.24468
M3 - Article
C2 - 19404952
AN - SCOPUS:66049085716
SN - 0004-3591
VL - 60
SP - 1250
EP - 1254
JO - Arthritis and rheumatism
JF - Arthritis and rheumatism
IS - 5
ER -