The problem of resistance in Mycobacterium tuberculosis may be underestimated in Africa

Simeon I.B. Cadmus; Olutayo I. Falodun; Oba E. Fagade; Robert Murphy; Babafemi Taiwo; Dick Van Soolingen

doi:10.4103/ijmy.ijmy_29_18

The problem of resistance in Mycobacterium tuberculosis may be underestimated in Africa

Simeon I.B. Cadmus^*, Olutayo I. Falodun, Oba E. Fagade, Robert Murphy, Babafemi Taiwo, Dick Van Soolingen

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The true burden of tuberculosis (TB) and particularly multidrug-resistant (MDR) TB in Sub-Saharan Africa has remained underestimated. Methods: We investigated drug susceptibility profile and genetic diversity of Mycobacterium tuberculosis isolates collected from confirmed tuberculosis patients in Ibadan, southwestern Nigeria. Results: We confirmed that from 74 randomly selected Mycobacterium tuberculosis isolates available for drug susceptibility testing in Ibadan, in 2011, 13.5% of them were MDR-TB. Conclusions: This figure is obviously above the national and World Health Organization figures.

Original language	English (US)
Pages (from-to)	148-151
Number of pages	4
Journal	International Journal of Mycobacteriology
Volume	7
Issue number	2
DOIs	https://doi.org/10.4103/ijmy.ijmy_29_18
State	Published - Apr 1 2018

Keywords

Africa
Nigeria
drug resistance
tuberculosis

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4103/ijmy.ijmy_29_18

Cite this

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title = "The problem of resistance in Mycobacterium tuberculosis may be underestimated in Africa",

abstract = "Background: The true burden of tuberculosis (TB) and particularly multidrug-resistant (MDR) TB in Sub-Saharan Africa has remained underestimated. Methods: We investigated drug susceptibility profile and genetic diversity of Mycobacterium tuberculosis isolates collected from confirmed tuberculosis patients in Ibadan, southwestern Nigeria. Results: We confirmed that from 74 randomly selected Mycobacterium tuberculosis isolates available for drug susceptibility testing in Ibadan, in 2011, 13.5% of them were MDR-TB. Conclusions: This figure is obviously above the national and World Health Organization figures.",

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note = "Funding Information: This research was partially funded by an African Doctoral Dissertation Research Fellowship award offered by the African Population and Health Research Center (APHRC) in partnership with the International Development Research Centre (IDRC) and Fogarty International/NIH grant (No. D43TW007995). Publisher Copyright: {\textcopyright} 2018 International Journal of Mycobacteriology | Published by Wolters Kluwer - Medknow.",

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AU - Cadmus, Simeon I.B.

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AU - Fagade, Oba E.

AU - Murphy, Robert

AU - Taiwo, Babafemi

AU - Van Soolingen, Dick

N1 - Funding Information: This research was partially funded by an African Doctoral Dissertation Research Fellowship award offered by the African Population and Health Research Center (APHRC) in partnership with the International Development Research Centre (IDRC) and Fogarty International/NIH grant (No. D43TW007995). Publisher Copyright: © 2018 International Journal of Mycobacteriology | Published by Wolters Kluwer - Medknow.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: The true burden of tuberculosis (TB) and particularly multidrug-resistant (MDR) TB in Sub-Saharan Africa has remained underestimated. Methods: We investigated drug susceptibility profile and genetic diversity of Mycobacterium tuberculosis isolates collected from confirmed tuberculosis patients in Ibadan, southwestern Nigeria. Results: We confirmed that from 74 randomly selected Mycobacterium tuberculosis isolates available for drug susceptibility testing in Ibadan, in 2011, 13.5% of them were MDR-TB. Conclusions: This figure is obviously above the national and World Health Organization figures.

AB - Background: The true burden of tuberculosis (TB) and particularly multidrug-resistant (MDR) TB in Sub-Saharan Africa has remained underestimated. Methods: We investigated drug susceptibility profile and genetic diversity of Mycobacterium tuberculosis isolates collected from confirmed tuberculosis patients in Ibadan, southwestern Nigeria. Results: We confirmed that from 74 randomly selected Mycobacterium tuberculosis isolates available for drug susceptibility testing in Ibadan, in 2011, 13.5% of them were MDR-TB. Conclusions: This figure is obviously above the national and World Health Organization figures.

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The problem of resistance in Mycobacterium tuberculosis may be underestimated in Africa

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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