The progression of untreated HIV-1 infection prior to AIDS

D. R. Hoover*, A. Saah, H. Bacellar, R. Murphy, B. Visscher, S. Metz, R. Anderson, R. A. Kaslow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Using a case-control study of untreated men, we investigated the physical, mental, and economic effects of human immunodeficiency virus (HIV-1) infection prior to the diagnosis of acquired immunodeficiency syndrome (AIDS). Beginning 2 to 2.5 years prior to AIDS, case subjects reported more of 12 HIV-1 related symptoms and during the year prior to AIDS, at least 30.6 extra days of these symptoms than did control subjects. Within the 6 months preceding AIDS, case subjects' unemployment rose to 9% (P ≤ .05) and depression to 34.2% (P ≤ .001). At 6 to 12 months and within 6 months before AIDS, 17.1% and 31.5%, respectively, were anemic, while 37.7% and 64.7% had CD4+ counts less than 200 x 106/L. Diagnosing AIDS at CD4+ counts less than 200 x 106/L could significantly reduce pre-AIDS morbidity. Other implications of these findings are discussed.

Original languageEnglish (US)
Pages (from-to)1538-1541
Number of pages4
JournalAmerican journal of public health
Issue number11
StatePublished - 1992

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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