The progressive nature of subaortic stenosis in congenital heart disease

Robert M. Freedom*, Andrew Pelech, Abe Brand, Michael Vogel, Peter M. Olley, Jeffrey Smallhorn, Richard D. Rowe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Data derived from serial hemodynamic and angiocardiographic investigations on pediatric patients not subjected to intervening intracardiac operations support the view that subaortic stenosis in congenital heart disease tends to be a progressive disorder. Our data are obtained from two groups of patients. The first comprised 22 patients with discrete subaortic stenosis in relative isolation. The second was made up of 19 patients with the fibrous or fibromuscular forms of discrete subaortic stenosis associated with a perimembranous ventricular septal defect. The results from both groups support our initial contention. The progressive character of subaortic stenosis in these two situations illustrates the dynamic nature of congenital heart disease, and the tendency of a changing form and function.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalInternational Journal of Cardiology
Issue number2
StatePublished - Jun 1985
Externally publishedYes


  • congenital heart disease
  • heart defects
  • natural history
  • subaortic diaphragmatic shelf
  • ventricular septal defect

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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