The PROMIS-Plus-Osteoarthritis of the Knee (OAK) profile measure integrates generic and condition-specific content to enhance relevance and efficiency

Susan Yount*, Michael A. Kallen, Karen E. Schifferdecker, Kathleen L. Carluzzo, Lynn M. Marshall, Kathryn Schabel, William Robb, David W. Manning, Elliott S. Fisher, David Cella

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The Patient-Reported Outcomes Measurement Information System (PROMIS)-Plus-Osteoarthritis of the Knee (OAK) profile integrates universal PROMIS items with knee-specific items across 13 domains. We evaluated the psychometric properties of a subset of six domains associated with quality of life in people with OAK. Study Design and Setting: In a cross-sectional study of OAK patients (n=600), we estimated reliability using Pearson and Spearman correlations with Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores and known-groups validity with PROMIS Global Health. Measure responsiveness was tested via paired t-tests in a longitudinal study (n=238), pre/post total knee replacement. Results: Across the six domains, internal consistency reliability (Cronbach's alpha) was 0.77−0.95 and test-retest reliability (intraclass correlation coefficients) was ≥0.90. Correlations with Knee Injury and Osteoarthritis Outcome Score (KOOS) subscores and PROMIS Global supported convergent and divergent validity. Known-groups validity testing revealed better scores in all domains for high vs. low global status groups, and knee-specific items added value in physical function and pain. All domains reflected (p<0.001) better health status scores at follow up. Conclusion: The six PROMIS-Plus-OAK profile domains demonstrated good psychometric characteristics. The measure integrates universal and knee-specific content to provide enhanced relevance, measurement precision and efficient administration for patient care and clinical research.

Original languageEnglish (US)
Pages (from-to)158-169
Number of pages12
JournalJournal of Clinical Epidemiology
Volume135
DOIs
StatePublished - Jul 2021

Keywords

  • Health outcomes
  • Knee
  • Osteoarthritis
  • PROMIS
  • Patient-reported outcomes
  • Questionnaires

ASJC Scopus subject areas

  • Epidemiology

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