The protean actions of neurotrophins and their receptors on the life and death of neurons

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112 Scopus citations

Abstract

At vanishingly low concentrations, factors of the neurotrophin family (NGF, BDNF, NT3 and NT4/5) can promote neuronal survival or death. Many investigations indicate that the survival-promoting signals of neurotrophins are generated by activation of Trk tyrosine kinase receptors and that their death-promoting signals are generated by activation of p75 neurotrophin receptors (p75NTR). Despite this, a body of work indicates that p75NTR can promote cell survival and Trk receptors can adversely affect neuron health. The potential mechanisms by which these receptors could have such diverse and antipodal effects are considered here.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalTrends in Neurosciences
Volume28
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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