The Protein Kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis

Amanda J. Redig, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The members of the protein kinase C (PKC) family of proteins play important roles in signaling for various growth factors, cytokines, and hormones. Extensive work over the years has led to the identification of three major groups of PKC isoforms. These include the classic PKCs (PKCα, PKCβI, PKCβII, PKCγ), the novel PKCs (PKCδ, PKCε, PKCη, PKCμ, PKCθ), and the atypical PKCs (PKCζ, PKCι/λ). All these PKC subtypes have been shown to participate in the generation of signals for important cellular processes and to mediate diverse and, in some cases, opposing biologic responses. There is emerging evidence that these kinases also play key functional roles in the regulation of cell growth, apoptosis, and differentiation of hematopoietic cells. In this review, both the engagement of the various PKC members in cytokine and growth factor signaling and their role in the regulation of hematopoiesis are discussed.

Original languageEnglish (US)
Pages (from-to)623-635
Number of pages13
JournalJournal of Interferon and Cytokine Research
Volume27
Issue number8
DOIs
StatePublished - Aug 2007

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

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