The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport

G. W.Gant Luxton, Joy I.Hsuan Lee, Sarah Haverlock-Moyns, Joseph Martin Schober, Gregory Allan Smith*

*Corresponding author for this work

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Transport of capsids in cells is critical to alphaherpesvirus infection and pathogenesis; however, viral factors required for transport have yet to be identified. Here we provide a detailed examination of capsid dynamics during the egress phase of infection in Vero cells infected with pseudorabies virus. We demonstrate that the VP1/2 tegument protein is required for processive microtubule-based transport of capsids in the cytoplasm. A second tegument protein that binds to VP1/2, UL37, was necessary for wild-type transport but was not essential for this process. Both proteins were also required for efficient nuclear egress of capsids to the cytoplasm.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalJournal of virology
Volume80
Issue number1
DOIs
StatePublished - Jan 2006

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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