The putative functional rs1045881 marker of neurexin-1 in schizophrenia and clozapine response

Tristram A P Lett, Arun K. Tiwari, Herbert Y. Meltzer, Jeffrey A. Lieberman, Steven G. Potkin, Aristotle N. Voineskos, James L. Kennedy, Daniel J. Müller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Neurexin-1 (NRXN1) modulates recruitment of NMDA receptors. Furthermore, clozapine reduces hyperactivity of NMDA receptors. Thus, regulation of the NRXN1 gene may mediate the efficacy of clozapine at reducing cortical hyperactivity. We examined the putative functional SNP, rs1045881, for association with schizophrenia, and the potential role of this SNP in clozapine response. The rs1045881 variant was not significantly associated with schizophrenia (N = 302 case-control pairs), but with clozapine response (N = 163; p = 0.030). Baseline and BPRS scores after six months revealed a trend for rs1045881 genotype by treatment interaction (p = 0.079). In the post hoc analysis, a significant association between BPRS negative symptoms score and genotype was observed (p = 0.033). These results suggest that the rs1045881 NRXN1 polymorphism may influence clozapine response.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalSchizophrenia Research
Volume132
Issue number2-3
DOIs
StatePublished - Nov 1 2011

Keywords

  • Antipsychotic medication
  • Antipsychotic response
  • Brief Psychiatric Rating Scale
  • Clozapine
  • Genetics
  • NXRN1
  • Neurexin-1 gene
  • Pharmacogenetics
  • Prospective treatment
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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