The PYRIN connection: Novel players in innate immunity and inflammation

Christian Stehlik*, John C. Reed

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.

Original languageEnglish (US)
Pages (from-to)551-558
Number of pages8
JournalJournal of Experimental Medicine
Issue number5
StatePublished - Sep 6 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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