TY - JOUR
T1 - The PYRIN connection
T2 - Novel players in innate immunity and inflammation
AU - Stehlik, Christian
AU - Reed, John C.
PY - 2004/9/6
Y1 - 2004/9/6
N2 - Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.
AB - Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.
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U2 - 10.1084/jem.20032234
DO - 10.1084/jem.20032234
M3 - Review article
C2 - 15353551
AN - SCOPUS:4544341107
SN - 0022-1007
VL - 200
SP - 551
EP - 558
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 5
ER -