The questionnaire for urinary incontinence diagnosis (QUID): Validity and responsiveness to change in women undergoing non-surgical therapies for treatment of stress predominant urinary incontinence

Catherine S. Bradley, David D. Rahn, Ingrid E. Nygaard, Matthew D. Barber, Charles W. Nager, Kimberly S. Kenton, Nazema Y. Siddiqui, Robert B. Abel, Cathie Spino, Holly E. Richter

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Aims: The Questionnaire for Urinary Incontinence Diagnosis (QUID), a 6-item urinary incontinence (UI) symptom questionnaire, was developed and validated to distinguish stress and urge UI. This study's objective was to evaluate QUID validity and responsiveness when used as a clinical trial outcome measure. Methods: Participants enrolled in a multi-center trial of non-surgical therapy (continence pessary, pelvic floor muscle training or combined) for stress-predominant UI and completed baseline and 3-month diaries, the Urinary Distress Inventory (UDI) and QUID. Data from all treatment groups were pooled. QUID internal consistency (Cronbach's α) and convergent/ discriminant validity (Pearson correlations) were evaluated. Responsiveness to change was assessed with 3-month score outcomes and distribution-based measurements. Results: Four hundred forty-four women (mean age 50) were enrolled with stress (N = 200) and mixed (N = 244) UI; 344 had 3-month data. Baseline QUID Stress and Urge scores (both scaled 0-15, larger values indicating worse UI) were 8.4 ± 3.2 and 4.5 ± 3.3, respectively. Internal consistency of QUID Total, Stress, and Urge scores was 0.75, 0.64 and 0.87, respectively. QUID Stress scores correlated moderately with UDI-Stress scores (r = 0.68, P < 0.0001) and diary stress UI episodes (r = 0.41, P < 0.0001). QUID Urge scores correlated moderately with UDI-Irritative scores (r = 0.68, P < 0.0001) and diary urge UI episodes (r = 0.45, P < 0.0001). Three-month QUID Stress and Urge scores improved (4.1 ± 3.4 and 2.2 ± 2.7, both P < 0.0001). QUID Stress score effect size (1.3) and standardized response mean (1.2) suggested a large change after therapy. Conclusion: The QUID has acceptable psychometric characteristics and may be used as a UI outcome measure in clinical trials.

Original languageEnglish (US)
Pages (from-to)727-734
Number of pages8
JournalNeurourology and Urodynamics
Volume29
Issue number5
DOIs
StatePublished - Jun 2010

Keywords

  • Outcome assessment
  • Questionnaires
  • Reliability and validity
  • Stress
  • Urinary incontinence

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology

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