The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment

Brenda J. Anderson*, S. John Gatley, David N. Rapp, Pamela S. Coburn-Litvak, Nora D. Volkow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The enriched environment (EC) causes morphological plasticity in striatal cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, 2-year-old rats had a higher ratio of D1 to muscarinic receptors in striatum relative to singly housed rats. Assays also showed trends for a greater ratio of D1 to cannabinoid receptors and a greater density of D1 receptors in striatum after EC. D2 receptor density was unaffected by the EC condition. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalBrain research
Volume872
Issue number1-2
DOIs
StatePublished - Jul 28 2000

Keywords

  • D2 receptor
  • Dopamine
  • Physical activity
  • Plasticity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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