The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment

Brenda J. Anderson; S. John Gatley; David N. Rapp; Pamela S. Coburn-Litvak; Nora D. Volkow

doi:10.1016/S0006-8993(00)02507-5

The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment

Brenda J. Anderson^*, S. John Gatley, David N. Rapp, Pamela S. Coburn-Litvak, Nora D. Volkow

^*Corresponding author for this work

School of Education and Social Policy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The enriched environment (EC) causes morphological plasticity in striatal cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, 2-year-old rats had a higher ratio of D1 to muscarinic receptors in striatum relative to singly housed rats. Assays also showed trends for a greater ratio of D1 to cannabinoid receptors and a greater density of D1 receptors in striatum after EC. D2 receptor density was unaffected by the EC condition. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	262-265
Number of pages	4
Journal	Brain research
Volume	872
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02507-5
State	Published - Jul 28 2000

Keywords

D2 receptor
Dopamine
Physical activity
Plasticity

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02507-5

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title = "The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment",

abstract = "The enriched environment (EC) causes morphological plasticity in striatal cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, 2-year-old rats had a higher ratio of D1 to muscarinic receptors in striatum relative to singly housed rats. Assays also showed trends for a greater ratio of D1 to cannabinoid receptors and a greater density of D1 receptors in striatum after EC. D2 receptor density was unaffected by the EC condition. (C) 2000 Elsevier Science B.V.",

keywords = "D2 receptor, Dopamine, Physical activity, Plasticity",

author = "Anderson, {Brenda J.} and Gatley, {S. John} and Rapp, {David N.} and Coburn-Litvak, {Pamela S.} and Volkow, {Nora D.}",

note = "Funding Information: This work was supported by Department of Energy/OBER and MH57845. We would like to thank Beatrice Pyatt for help with receptor assays, and Jack Travis for helping care for the animals. The Dept. of Laboratory Animal Resources generously supplied the enriched environment cages.",

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doi = "10.1016/S0006-8993(00)02507-5",

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pages = "262--265",

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T1 - The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment

AU - Anderson, Brenda J.

AU - Gatley, S. John

AU - Rapp, David N.

AU - Coburn-Litvak, Pamela S.

AU - Volkow, Nora D.

N1 - Funding Information: This work was supported by Department of Energy/OBER and MH57845. We would like to thank Beatrice Pyatt for help with receptor assays, and Jack Travis for helping care for the animals. The Dept. of Laboratory Animal Resources generously supplied the enriched environment cages.

PY - 2000/7/28

Y1 - 2000/7/28

N2 - The enriched environment (EC) causes morphological plasticity in striatal cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, 2-year-old rats had a higher ratio of D1 to muscarinic receptors in striatum relative to singly housed rats. Assays also showed trends for a greater ratio of D1 to cannabinoid receptors and a greater density of D1 receptors in striatum after EC. D2 receptor density was unaffected by the EC condition. (C) 2000 Elsevier Science B.V.

AB - The enriched environment (EC) causes morphological plasticity in striatal cells that express D1 and D2 receptors. We used radioligand binding assays to examine whether EC produces plasticity in striatal receptor density and receptor density ratios. After 30 days of EC, 2-year-old rats had a higher ratio of D1 to muscarinic receptors in striatum relative to singly housed rats. Assays also showed trends for a greater ratio of D1 to cannabinoid receptors and a greater density of D1 receptors in striatum after EC. D2 receptor density was unaffected by the EC condition. (C) 2000 Elsevier Science B.V.

KW - D2 receptor

KW - Dopamine

KW - Physical activity

KW - Plasticity

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The ratio of striatal D1 to muscarinic receptors changes in aging rats housed in an enriched environment

Abstract

Keywords

ASJC Scopus subject areas

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