The relation between baseline HIV drug resistance and response to antiretroviral therapy: Re-analysis of retrospective and prospective studies using a standardized data analysis plan

Victor DeGruttola, Lynn Dix, Richard D'Aquila, Dan Holder, Andrew Phillips, Mounir Ait-Khaled, John Baxter, Philippe Clevenbergh, Scott Hammer, Richard Harrigan, David Katzenstein, Randall Lanier, Michael Miller, Michael Para, Sabine Yerly, Andrew Zolopa, Jeffrey Murray, Amy Patick, Veronica Miller, Steven CastilloLouise Pedneault, John Mellors*

*Corresponding author for this work

Research output: Contribution to journalArticle

297 Scopus citations

Abstract

To assess the relation between resistance to antiretroviral drugs for treatment of HIV-1 infection and virological response to therapy, results from 12 different studies were re-analysed according to a standard data analysis plan. These studies included nine clinical trials and three observational cohorts. The primary end-point in our analyses was virological failure by week 24. Baseline factors that were investigated as predictors of virological failure were plasma HIV-1 RNA, the number and type of new antivetuoviral drugs in the regimen, and viral susceptibility to the drugs in the regimen, determined by genotyping or phenotyping methods. These analyses confirmed the importance of both genotypic and phenotypic drug resistance as predictors of virological failure, whether these factors were analysed separately or adjusted for other baseline confounding factors. In most of the re-analysed studies, the odds of virological failure were reduced by about twofold for each additional drug in the regimen to which the patient's virus was sensitive by genotyping methods, and by about two- to threefold for each additional drug that was sensitive by phenotyping.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalAntiviral Therapy
Volume5
Issue number1
StatePublished - 2000

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'The relation between baseline HIV drug resistance and response to antiretroviral therapy: Re-analysis of retrospective and prospective studies using a standardized data analysis plan'. Together they form a unique fingerprint.

  • Cite this

    DeGruttola, V., Dix, L., D'Aquila, R., Holder, D., Phillips, A., Ait-Khaled, M., Baxter, J., Clevenbergh, P., Hammer, S., Harrigan, R., Katzenstein, D., Lanier, R., Miller, M., Para, M., Yerly, S., Zolopa, A., Murray, J., Patick, A., Miller, V., ... Mellors, J. (2000). The relation between baseline HIV drug resistance and response to antiretroviral therapy: Re-analysis of retrospective and prospective studies using a standardized data analysis plan. Antiviral Therapy, 5(1), 41-48.