TY - JOUR
T1 - The relationship between alfentanil distribution kinetics and cardiac output
AU - Henthorn, Thomas K.
AU - Krejcie, Tom C
AU - Avram, Michael J
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The relationship between cardiac output and the tissue distribution of alfentanil was investigated in seven healthy volunteers. Subjects were given 10 µg/kg alfentanil and 0.5 mg/kg indocyanine green. Arterial blood samples were obtained at baseline, 1 minute, every ½ minute until 5 minutes, and then every minute until 15 minutes after the drug injection was begun. Subsequent samples were collected to 6 hours. Cardiac output was measured continuously by use of thoracic bioimpedance. Alfentanil pharmacokinetics were modeled with both a standard three‐compartment model and a four‐compartmental model based in part on the two‐compartmental pharmacokinetics of indocyanine green. The sum of intercompartmental clearances for both the three‐ and four‐compartment models were significantly correlated with the measured cardiac outputs, r = 0.93 and r = 0.88, respectively. These findings indicate that the intercompartmental clearance (i.e., tissue distribution) of alfentanil is largely determined by cardiac output (i.e., tissue blood flow). Clinical Pharmacology and Therapeutics (1992) 52, 190–196; doi:
AB - The relationship between cardiac output and the tissue distribution of alfentanil was investigated in seven healthy volunteers. Subjects were given 10 µg/kg alfentanil and 0.5 mg/kg indocyanine green. Arterial blood samples were obtained at baseline, 1 minute, every ½ minute until 5 minutes, and then every minute until 15 minutes after the drug injection was begun. Subsequent samples were collected to 6 hours. Cardiac output was measured continuously by use of thoracic bioimpedance. Alfentanil pharmacokinetics were modeled with both a standard three‐compartment model and a four‐compartmental model based in part on the two‐compartmental pharmacokinetics of indocyanine green. The sum of intercompartmental clearances for both the three‐ and four‐compartment models were significantly correlated with the measured cardiac outputs, r = 0.93 and r = 0.88, respectively. These findings indicate that the intercompartmental clearance (i.e., tissue distribution) of alfentanil is largely determined by cardiac output (i.e., tissue blood flow). Clinical Pharmacology and Therapeutics (1992) 52, 190–196; doi:
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U2 - 10.1038/clpt.1992.129
DO - 10.1038/clpt.1992.129
M3 - Article
C2 - 1505154
AN - SCOPUS:0026783621
VL - 52
SP - 190
EP - 196
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 2
ER -