The relationship between heart disease and cognitive impairment

Kristin L. Miller*, Laura Pedelty, Fernando D. Testai

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Neurodegenerative dementias, such as Alzheimer's disease, and vascular cognitive impairment were once considered unrelated processes. Emerging evidence, however, shows that both conditions often coexist and that vascular risk factors in midlife predispose to the development of cognitive decline later in older adults. In addition, recent advanced in basic science research have elucidated key underpinnings of this association. In this chapter, we review the clinical and basic science data that explain the relationship between vascular risk factors, heart disease, and cognitive decline.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Number of pages15
StatePublished - Jan 2021

Publication series

NameHandbook of Clinical Neurology
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152


  • Alzheimer disease
  • Brain health
  • Cognitive decline
  • Dementia
  • Heart disease
  • Mild cognitive impairment
  • Neurodegeneration
  • Vascular cognitive impairment
  • Vascular risk factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'The relationship between heart disease and cognitive impairment'. Together they form a unique fingerprint.

Cite this