The relationship of insulin-like growth factor 2 to fetal growth and adiposity

Rachel Kadakia, Jami Josefson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Insulin-like growth factor 2 (IGF-2) is necessary for adequate human growth. Overexpression of the IGF2 gene is associated with fetal overgrowth and may play a role in the intrauterine programming of adipose tissue. As obesity in children is a major public health problem associated with early onset of comorbid metabolic diseases, identifying early life markers of obesity may serve as useful tool for counseling and implementation of preventive efforts before obesity develops. The relationship between IGF-2 and body composition is an emerging field of study and existing data are conflicting. In this review, we discuss the IGF2 gene and its function, highlight the proposed mechanisms for the effects of IGF-2 on adiposity, and examine the current literature studying the relationships between IGF-2 levels, changes within the IGF2 gene, weight, and adiposity. With additional study, IGF-2 may emerge as a useful marker of future obesity risk in infants.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalHormone Research in Paediatrics
Volume85
Issue number2
DOIs
StatePublished - 2016

Keywords

  • Body composition
  • Insulin-like growth factor 2
  • Intrauterine growth
  • Neonatal adiposity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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