The relationship of Sindbis virus assembly and the viral protein 6K with intermediate filaments

D. Wu*, W. Xu, R. Jiao, M. Ding, Z. Zhai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The relationship of Sindbis virus (Sbv) assembly with intermediate filaments was studied by means of whole-mount and DGD embedment-free technique of EM together with the procedure of gentle extraction. In the early stage of Sbv infection, the "virus assembly center" was suspended in the intermediate filament network. In the late stage, the assembling and assembled virus nucleocapsids were associated with intermediate filaments. It is presumable that the virus nucleocapsids may move from the "virus assembly center" to cytoplasmic membrane along the intermediate filaments. Further study using immunolabelling technique indicated that the nonstructural protein 6K of Sbv was probably associated with intermediate filaments as well.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalWei sheng wu xue bao = Acta microbiologica Sinica
Volume30
Issue number6
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Medicine(all)

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