The relevance of NF-κB for CD95 signaling in tumor cells

Patrick Legembre, Bryan C. Barnhart, Marcus E. Peter*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Most members of the death receptor family including CD95 (APO-1/Fas) have been shown to induce both apoptosis as well as non-apoptotic pathways depending on the tissue and the circumstances. One of the non-apoptotic pathways emanating from CD95, activation of NF-κB, has recently been demonstrated to regulate invasiveness of apoptosis resistant tumor cells. In contrast, activation of NF-κB in apoptosing cells is believed to be suppressed due to cleavage of various NF-κB pathway components by active caspases that execute apoptosis. We now present data demonstrating that in certain highly CD95 apoptosis sensitive cells NF-κB is robustly activated. In fact overexpression of apoptosis inhibitors such as Bcl-2 or c-FLIPL in these cells results in decreased activation of NF-κB through CD95. We propose a model in which NF-κB is generally activated in certain cells but may have different functions depending on whether cells are programmed to die or to survive.

Original languageEnglish (US)
Pages (from-to)1235-1239
Number of pages5
JournalCell Cycle
Volume3
Issue number10
DOIs
StatePublished - Oct 2004

Keywords

  • Bcl-2
  • Fas
  • Invasiveness
  • NF-κB
  • c-FLIP

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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