TY - JOUR
T1 - The renin-angiotensin and fibrinolytic systems
T2 - Co-conspirators in the pathogenesis of ischemic cardiovascular disease
AU - Brown, Nancy J.
AU - Vaughan, Douglas E.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health (NIH HL-14192 and HL-51387). N.J.B. is a Clinical Associate Physician, General Clinical Research Center (MOI-RR00095-533). D.E.V. is the recipient of a Clinical Investigator Award from the Department of Veterans Affairs Research Administration.
PY - 1996/10
Y1 - 1996/10
N2 - In vitro and in vivo data provide evidence for an interaction between the renin-angiotensin and fibrinolytic systems. Angiotensin-converting enzyme (ACE) is strategically poised to regulate this interaction. ACE catalyzes the conversion of angiotensin I to angiotensin II (Ang), and Ang II stimulates release of PAI-1, the major inhibitor of tissue-type plasminogen activator (t-PA) and urokinase in the vasculature. Conversely, ACE catalyzes the breakdown of bradykinin, a potent stimulus of t-PA secretion. This interaction between the renin angiotensin and fibrinolytic systems may partially explain the clinical observation that stimulation or suppression of the renin-angiotensin system can alter the risk of ischemic cardiovascular events.
AB - In vitro and in vivo data provide evidence for an interaction between the renin-angiotensin and fibrinolytic systems. Angiotensin-converting enzyme (ACE) is strategically poised to regulate this interaction. ACE catalyzes the conversion of angiotensin I to angiotensin II (Ang), and Ang II stimulates release of PAI-1, the major inhibitor of tissue-type plasminogen activator (t-PA) and urokinase in the vasculature. Conversely, ACE catalyzes the breakdown of bradykinin, a potent stimulus of t-PA secretion. This interaction between the renin angiotensin and fibrinolytic systems may partially explain the clinical observation that stimulation or suppression of the renin-angiotensin system can alter the risk of ischemic cardiovascular events.
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U2 - 10.1016/S1050-1738(96)00091-6
DO - 10.1016/S1050-1738(96)00091-6
M3 - Article
C2 - 21232303
AN - SCOPUS:0030273406
SN - 1050-1738
VL - 6
SP - 239
EP - 243
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 7
ER -
