The renin-angiotensin and fibrinolytic systems: Co-conspirators in the pathogenesis of ischemic cardiovascular disease

Nancy J. Brown*, Douglas E. Vaughan

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

In vitro and in vivo data provide evidence for an interaction between the renin-angiotensin and fibrinolytic systems. Angiotensin-converting enzyme (ACE) is strategically poised to regulate this interaction. ACE catalyzes the conversion of angiotensin I to angiotensin II (Ang), and Ang II stimulates release of PAI-1, the major inhibitor of tissue-type plasminogen activator (t-PA) and urokinase in the vasculature. Conversely, ACE catalyzes the breakdown of bradykinin, a potent stimulus of t-PA secretion. This interaction between the renin angiotensin and fibrinolytic systems may partially explain the clinical observation that stimulation or suppression of the renin-angiotensin system can alter the risk of ischemic cardiovascular events.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume6
Issue number7
DOIs
StatePublished - Oct 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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