The response of hepatocyte cell volume to hyperthermia and its role in oedema

D. P. O'Neill; T. Peng; S. J. Payne

doi:10.1109/IEMBS.2011.6091069

The response of hepatocyte cell volume to hyperthermia and its role in oedema

D. P. O'Neill^*, T. Peng, S. J. Payne

^*Corresponding author for this work

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.

Original language	English (US)
Title of host publication	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Pages	4305-4308
Number of pages	4
DOIs	https://doi.org/10.1109/IEMBS.2011.6091069
State	Published - Dec 26 2011
Event	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 - Boston, MA, United States Duration: Aug 30 2011 → Sep 3 2011

Other

Other	33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Country/Territory	United States
City	Boston, MA
Period	8/30/11 → 9/3/11

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/IEMBS.2011.6091069

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title = "The response of hepatocyte cell volume to hyperthermia and its role in oedema",

abstract = "A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.",

author = "O'Neill, {D. P.} and T. Peng and Payne, {S. J.}",

year = "2011",

month = dec,

day = "26",

doi = "10.1109/IEMBS.2011.6091069",

language = "English (US)",

isbn = "9781424441211",

pages = "4305--4308",

booktitle = "33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011",

note = "33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 ; Conference date: 30-08-2011 Through 03-09-2011",

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O'Neill, DP, Peng, T & Payne, SJ 2011, The response of hepatocyte cell volume to hyperthermia and its role in oedema. in 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011., 6091069, pp. 4305-4308, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011, Boston, MA, United States, 8/30/11. https://doi.org/10.1109/IEMBS.2011.6091069

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AU - Payne, S. J.

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Y1 - 2011/12/26

N2 - A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.

AB - A novel mathematical model for hepatocytes and surrounding volume is presented here; in addition to tracking ion transport and diffusion the new model allows for changing cell volume. Using temporally and spatially varying temperature as an input, this paper shows how differences between diffusion coefficients directly influence increases in cell volume. The multiscale nature of the model presents a possible link from established cellular equations to the observed clinical result of oedema present in thermal treatments of cancer.

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BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011

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ER -

The response of hepatocyte cell volume to hyperthermia and its role in oedema

Abstract

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ASJC Scopus subject areas

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