The restriction factors of human immunodeficiency virus

Reuben S. Harris*, Judd F. Hultquist, David T. Evans

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

191 Scopus citations

Abstract

Cellular proteins called "restriction factors" can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination by promoting APOBEC3 protein degradation; how the viral Vpu, Env, and Nef proteins facilitate internalization and degradation of the virus-tethering protein BST-2/tetherin; and how the viral Vpx protein prevents the premature termination of reverse transcription by degrading the dNTPase SAMHD1. These HIV restriction and counter-restriction mechanisms suggest strategies for new therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)40875-40883
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number49
DOIs
StatePublished - Nov 30 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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