The Right Ventricle in the Trans-Catheter Era: A Perspective for Planning Interventions

Jared L. Antevil*, Michael A. Napolitano, Federico E. Mordini, Patrick M. McCarthy, Gregory D. Trachiotis

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Dysfunction of the right ventricle (RV) is common in patients with advanced left-sided valve disease and the significant impact of RV dysfunction on both short and long-term outcome is well established. However, considerations of RV function are largely absent in current management guidelines for valve disease and cardiac procedural risk models. As the indications and use of trans-catheter therapies rapidly expand for patients with acquired valvular disease, it is critical for clinicians to understand and consider RV function when making decisions for these patients. This review summarizes contemporary data on the assessment of RV function, the prognostic importance of baseline RV dysfunction on surgical and transcatheter procedures for acquired left-sided valvular disease, and the relative impact of these interventions on RV function. Baseline RV dysfunction is a powerful predictor of poor short- and long-term outcome after any therapeutic intervention for acquired left-sided cardiac valve disease. Surgical intervention for aortic or mitral valve disease is associated with a significant but transient decline in RV function, whereas trans-catheter procedures generally do not appear to have detrimental effects on either longitudinal or global RV function. Guidelines for therapy in patents with acquired left-sided valvular disease should account for RV dysfunction. Whereas surgical intervention in these patients leads to a predictable decline in RV function, trans-catheter therapies largely do not appear to have this effect. Further study is needed to determine the impact of these findings on current practice.

Original languageEnglish (US)
Pages (from-to)892-901
Number of pages10
JournalSeminars in thoracic and cardiovascular surgery
Issue number3
StatePublished - Sep 1 2022


  • Left-sided valve disease
  • Right ventricle
  • Transcatheter interventions

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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