The rise and promise of molecular nanotopology

Qing Hui Guo*, Yang Jiao, Yuanning Feng, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Molecular nanotopology-a term we coined recently -is a rapidly developing field of research that is emerging out of the confluence of chemical topology with the mechanical bond. When perusing the increased research activities in this field, it is clear that a new discipline is ready to receive recognition in its own right. In this Mini-Review, we address the historical development of chemical topology and describe how the rational design and practical synthesis of molecular links and knots with mechanical bonds, together with interwoven extended frameworks, have led to the rapid establishment of molecular nanotopology as a discipline. Representative examples are highlighted to offer the reader an extensive overview of ongoing research. We spotlight the major challenges facing chemists and materials scientists and provide some indications as to how molecular nanotopology is going to develop in the years ahead.

Original languageEnglish (US)
Pages (from-to)1542-1572
Number of pages31
JournalCCS Chemistry
Issue number7
StatePublished - Jul 2021


  • Chemical topology
  • Helicates
  • Interwoven grids
  • Mechanical bonds
  • Molecular knots
  • Molecular links
  • Nanoconfinement
  • Networks
  • Template synthesis
  • Topological chirality

ASJC Scopus subject areas

  • General Chemistry


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