This study was aimed at investigating the impact of antiepileptic drugs (AEDs) on hyperhomocysteinemia (hyper-Hcy) in 71 epileptic patients (pts) (40 M, 31 F; 19-41 aa) exhibiting the CT677/AC1298 diplotype of MTHFR gene. 26 pt (36.6%) showed hyper-Hcy (> 13 μmol/); of them, 20 were treated with enzyme-inducing AEDs and 6 with enzyme-inducing AEDs added on to non enzyme inducing drugs. Pts exclusively treated with enzyme-inducing AEDs exhibited lower serum folate concentrations (3.28 ± 1.82 nmol/L p < 0.01) and higher plasma Hey levels (18.32 ± 5.52 μmol/L p < 0.001) as compared to other groups. These pts showed a positive risk association for hyper-Hcy (OR = 3.8, CI = 1.04-14.4). Folate supplementation (5 mg/day) restored both Hcy and folate levels within the normal ranges.
|Translated title of the contribution||The risk of hyperhomocysteinemia in patients with epilepsy exhibiting the diplotype C677T/A1298C of MTHFR|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|State||Published - 2005|
- Antiepileptic drugs
ASJC Scopus subject areas
- Clinical Neurology