The Road Ahead for Metal-Organic Frameworks: Current Landscape, Challenges and Future Prospects

Michael L. Barsoum; Kira M. Fahy; William Morris; Vinayak P. Dravid; Benjamin Hernandez; Omar K. Farha

doi:10.1021/acsnano.4c14744

The Road Ahead for Metal-Organic Frameworks: Current Landscape, Challenges and Future Prospects

Michael L. Barsoum, Kira M. Fahy, William Morris, Vinayak P. Dravid, Benjamin Hernandez, Omar K. Farha^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

This perspective highlights the transformative potential of Metal-Organic Frameworks (MOFs) in environmental and healthcare sectors. It discusses work that has advanced beyond technology readiness levels of >4 including applications in capture, storage, and conversion of gases to value added products. This work showcases efforts in the most salient applications of MOFs which have been performed at a great cadence, enabled by the federal government, large companies, and startups to commercialize these technologies despite facing significant challenges. This article also forecasts the role of nanoscale MOFs in healthcare, including strides toward personalized medicine, advocating for their use in custom-tailored drug delivery systems. Finally we underscore the potential acceleration in MOF research and development through the integration of machine learning and AI, positioning MOFs as versatile tools poised to address global sustainability and health challenges.

Original language	English (US)
Pages (from-to)	13-20
Number of pages	8
Journal	ACS nano
Volume	19
Issue number	1
DOIs	https://doi.org/10.1021/acsnano.4c14744
State	Published - Jan 14 2025

Funding

K.M.F. is supported by the National Science Foundation Graduate Research Fellowship (NSF GRFP) under Grant No. DGE-1842165. M.L.B. and K.M.F. would like to acknowledge support from the Ryan Fellowship and the International Institute for Nanotechnology at Northwestern University. O.K.F. gratefully acknowledges support from the Defense Threat Reduction Agency (HDTRA1-19-1-0007) and the U.S. Department of Energy (DE-SC0022332) and the Catalyst Design for Decarbonization Center, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Basic Energy Sciences (DE-SC0023383). V.P.D. gratefully acknowledges partial support from the Trienens Institute for Sustainability and Energy at Northwestern University and the Soft and Hybrid nanotechnology Experimental Resource (NSF ECCS-2025633), the IIN, and Northwestern\u2019s MSERC program (NSF DMR-1720139).

Keywords

atmospheric water harvesting
direct air capture
large language models
metal−organic framework

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/acsnano.4c14744

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abstract = "This perspective highlights the transformative potential of Metal-Organic Frameworks (MOFs) in environmental and healthcare sectors. It discusses work that has advanced beyond technology readiness levels of >4 including applications in capture, storage, and conversion of gases to value added products. This work showcases efforts in the most salient applications of MOFs which have been performed at a great cadence, enabled by the federal government, large companies, and startups to commercialize these technologies despite facing significant challenges. This article also forecasts the role of nanoscale MOFs in healthcare, including strides toward personalized medicine, advocating for their use in custom-tailored drug delivery systems. Finally we underscore the potential acceleration in MOF research and development through the integration of machine learning and AI, positioning MOFs as versatile tools poised to address global sustainability and health challenges.",

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The Road Ahead for Metal-Organic Frameworks: Current Landscape, Challenges and Future Prospects

Abstract

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Keywords

ASJC Scopus subject areas

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