The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis

Joshua L. Owen, Paras P. Vakharia, Jonathan I Silverberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Patients with atopic dermatitis (AD) have increased penetration of allergens, immune dysregulation (including shared cytokine pathways), and frequent use of emollients and topical medications, all of which may predispose toward developing allergic contact dermatitis (ACD). Recent systematic reviews have suggested that ACD is a significant clinical problem in both children and adults with AD. While this remains controversial, ACD remains an important comorbidity and potential exacerbant of AD in clinical practice. Common relevant allergens, include lanolin, neomycin, formaldehyde, sesquiterpene lactone mix, compositae mix, and fragrances that are commonly found in AD patients’ personal care products. We herein review the clinical scenarios where patch testing is indicated in AD. In addition, we review the contraindications, preferred patch-testing series, pitfalls, and challenges determining the relevance of positive patch-test reactions in AD patients.

Original languageEnglish (US)
Pages (from-to)293-302
Number of pages10
JournalAmerican Journal of Clinical Dermatology
Issue number3
StatePublished - Jun 1 2018

ASJC Scopus subject areas

  • Dermatology


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