The role of a LAR-like receptor tyrosine phosphatase in growth cone collapse and mutual-avoidance by sibling processes

Fumio Nakamura, Robert G. Kalb, Stephen M. Strittmatter

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Among the many cells or parts of cells that a growth cone may encounter during its embryonic migrations are other processes or parts of its parent cell. Such an event can be expected to be relatively frequent in the genesis of neuronal arbors, for instance, where the density of innervation of a target region can be quite high. Few experimental studies have addressed the very interesting question of whether a process 'recognizes' siblings in some unique way, in a manner that can be distinguished from, say, how it interacts with unrelated cells. One example can be found in the leech, where sibling branches in the terminal fields of identified mechanosensory cells avoid each other strictly while permitting some significant continuing contact and overlap with homologues, a phenomenon that has been dubbed 'self-avoidance.' Another example has been reported in cultured Helisoma neurons, where severing a branch of a neuron allows sibling neurites to form electrical junctions with it, although normally sibling neurites do not do so. In both of these instances, coincidental activity was proposed as one means to achieve recognition of self and as possibly leading to the blocking of a continuing interaction among the parts, although alternative explanations were indeed considered possible. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)194-203
Number of pages10
JournalJournal of Neurobiology
Volume44
Issue number2
DOIs
StatePublished - Aug 24 2000

Keywords

  • Comb cells
  • LAR-like receptor
  • Mechanosensory cells
  • Mutual avoidance
  • Notch receptor
  • Self-recognition mechanism

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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