The role of astrocytes, oligodendrocytes, microglia and endothelial cells in TMEV infection

M. C. Dal Canto; C. L. Vanderlugt

doi:10.1007/0-387-25518-4_30

The role of astrocytes, oligodendrocytes, microglia and endothelial cells in TMEV infection

M. C. Dal Canto^*, C. L. Vanderlugt

^*Corresponding author for this work

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Chronic TMEV infection in susceptible strains leads to an inflammatory demyelinating disease modeling MS. TMEV antigen can be found abundantly in microglia and infiltrating macrophage, but viral growth is restricted in these cells. Viral persistence has been seen in astrocytes, microglia, and oligodendrocytes. However, infiltrating macrophage and, to some extent, resident microglia play an important role in antigen presentation, inflammation and epitope spreading.

Original language	English (US)
Title of host publication	Experimental Models of Multiple Sclerosis
Publisher	Springer US
Pages	617-628
Number of pages	12
ISBN (Electronic)	9780387255187
ISBN (Print)	0387255176, 9780387255170
DOIs	https://doi.org/10.1007/0-387-25518-4_30
State	Published - Jan 1 2005

Keywords

Theiler's virus infection
astrocytes
demyelination
epitope spreading
microglial cells
oligodendrocytes
viral persistence

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)

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10.1007/0-387-25518-4_30

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abstract = "Chronic TMEV infection in susceptible strains leads to an inflammatory demyelinating disease modeling MS. TMEV antigen can be found abundantly in microglia and infiltrating macrophage, but viral growth is restricted in these cells. Viral persistence has been seen in astrocytes, microglia, and oligodendrocytes. However, infiltrating macrophage and, to some extent, resident microglia play an important role in antigen presentation, inflammation and epitope spreading.",

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N2 - Chronic TMEV infection in susceptible strains leads to an inflammatory demyelinating disease modeling MS. TMEV antigen can be found abundantly in microglia and infiltrating macrophage, but viral growth is restricted in these cells. Viral persistence has been seen in astrocytes, microglia, and oligodendrocytes. However, infiltrating macrophage and, to some extent, resident microglia play an important role in antigen presentation, inflammation and epitope spreading.

AB - Chronic TMEV infection in susceptible strains leads to an inflammatory demyelinating disease modeling MS. TMEV antigen can be found abundantly in microglia and infiltrating macrophage, but viral growth is restricted in these cells. Viral persistence has been seen in astrocytes, microglia, and oligodendrocytes. However, infiltrating macrophage and, to some extent, resident microglia play an important role in antigen presentation, inflammation and epitope spreading.

KW - Theiler's virus infection

KW - astrocytes

KW - demyelination

KW - epitope spreading

KW - microglial cells

KW - oligodendrocytes

KW - viral persistence

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BT - Experimental Models of Multiple Sclerosis

PB - Springer US

ER -

The role of astrocytes, oligodendrocytes, microglia and endothelial cells in TMEV infection

Abstract

Keywords

ASJC Scopus subject areas

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