The role of astrocytes, oligodendrocytes, microglia and endothelial cells in TMEV infection

M. C. Dal Canto*, C. L. Vanderlugt

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Chronic TMEV infection in susceptible strains leads to an inflammatory demyelinating disease modeling MS. TMEV antigen can be found abundantly in microglia and infiltrating macrophage, but viral growth is restricted in these cells. Viral persistence has been seen in astrocytes, microglia, and oligodendrocytes. However, infiltrating macrophage and, to some extent, resident microglia play an important role in antigen presentation, inflammation and epitope spreading.

Original languageEnglish (US)
Title of host publicationExperimental Models of Multiple Sclerosis
PublisherSpringer US
Pages617-628
Number of pages12
ISBN (Electronic)9780387255187
ISBN (Print)0387255176, 9780387255170
DOIs
StatePublished - Jan 1 2005

Keywords

  • Theiler's virus infection
  • astrocytes
  • demyelination
  • epitope spreading
  • microglial cells
  • oligodendrocytes
  • viral persistence

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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    Dal Canto, M. C., & Vanderlugt, C. L. (2005). The role of astrocytes, oligodendrocytes, microglia and endothelial cells in TMEV infection. In Experimental Models of Multiple Sclerosis (pp. 617-628). Springer US. https://doi.org/10.1007/0-387-25518-4_30