Abstract
Chronic TMEV infection in susceptible strains leads to an inflammatory demyelinating disease modeling MS. TMEV antigen can be found abundantly in microglia and infiltrating macrophage, but viral growth is restricted in these cells. Viral persistence has been seen in astrocytes, microglia, and oligodendrocytes. However, infiltrating macrophage and, to some extent, resident microglia play an important role in antigen presentation, inflammation and epitope spreading.
| Original language | English (US) |
|---|---|
| Title of host publication | Experimental Models of Multiple Sclerosis |
| Publisher | Springer US |
| Pages | 617-628 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780387255187 |
| ISBN (Print) | 0387255176, 9780387255170 |
| DOIs | |
| State | Published - Jan 1 2005 |
Keywords
- Theiler's virus infection
- astrocytes
- demyelination
- epitope spreading
- microglial cells
- oligodendrocytes
- viral persistence
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)