The role of biologics in ulcerative colitis

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3 Scopus citations

Abstract

Since the introduction of anti-TNF agents for the treatment of Crohn's disease there has been interest in the potential for treating ulcerative colitis with biological therapies. Early observational series suggested a benefit in the setting of severe, hospitalized patients. However, the recent completion of two large multi-center, double-blind placebo-controlled trials confirmed a role for infliximab for outpatients with refractory, moderate-severe disease with evidence for clinical remissions, mucosal healing, and a reduction in colectomies. Despite this evidence, there are numerous questions remaining regarding the optimal positioning in the setting of moderate-severe disease, potential benefits of concomitant immune suppression and the need for maintenance treatment after induction therapy. Additional clinical trials have demonstrated a less profound benefit for adalimumab at similar doses that are used in Crohn's disease. Other biological agents that have targeted T cells such as visiluzimab and abatacept were not demonstrated to be effective in controlled trials.

Original languageEnglish (US)
Pages (from-to)497-500
Number of pages4
JournalDigestive Diseases
Volume28
Issue number3
DOIs
StatePublished - Oct 1 2010

Keywords

  • Adalimumab
  • Biologics
  • Infliximab
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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