The role of chaperones in polyglutamine disease

Puneet Opal, Huda Y. Zoghbi*

*Corresponding author for this work

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

The'triplet repeat' neurodegenerative diseases are linked by a common mode of pathogenicity, wherein a polyglutamine expansion within the relevant disease-causing protein induces toxicity. Although details underlying pathogenesis are largely unknown, protein chaperones appear to be effective suppressors of toxicity in various experimental models. Understanding the protective role of chaperones might not only help us to understand the biology of polyglutamine toxicity, but also, and perhaps more importantly, inspire the design of novel therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)232-236
Number of pages5
JournalTrends in Molecular Medicine
Volume8
Issue number5
DOIs
StatePublished - May 20 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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