The role of chemotherapy and prophylactic bilateral oophorectomy in a case of colorectal adenocarcinoma with ovarian metastases

Eon K. Shin*, Bayan T. Takizawa, Louise Masters, Shohreh Shahabi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A 66-year-old female presented with a large abdominal mass and accompanying systemic complaints of abdominal pain, constipation, and fever. On exploratory laparotomy, the mass was found to be a moderately differentiated adenocarcinoma of the sigmoid colon with metastasis to the left ovary. A primary colorectal carcinoma that has metastasized to the ovaries can be difficult to distinguish clinically from an advanced primary ovarian tumor. Histology and tumor markers are currently the most useful tools available in making an accurate diagnosis. If the nature of the primary tumor is uncertain and the initial response to chemotherapy is poor, the patient's prognosis will also be poor. Though controversy exists regarding the role of prophylactic bilateral oophorectomy during resection for primary colorectal cancer, later confusion can be avoided by performing this procedure when the colorectal carcinoma is first diagnosed. However, the possibility of a concurrent primary ovarian tumor must not be overlooked.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalYale Journal of Biology and Medicine
Volume74
Issue number2
StatePublished - Mar 1 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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