The role of cytokine deficiencies and cytokine autoantibodies in clinical dermatology

Walter Joseph Liszewski*, R. Gniadecki

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cytokines are small, secreted proteins that are essential for promoting and maintaining a normal immune response. Upregulation of cytokines frequently occurs in autoimmune and inflammatory diseases. Conversely, several immunodeficiency, autoimmune and autoinflammatory disorders are known to occur due to a downregulation or absence of cytokines. Here, we review the diagnosis and clinical management of cytokine deficiency syndromes in dermatology. We will review the biology of cytokines, and the current approved indications for recombinant cytokines and anticytokine antibodies. We will also review the role of cytokine deficiencies and cytokine autoantibodies in immunodeficiency syndromes, as well as in autoimmune disorders. Finally, we will examine autoinflammatory disorders due to cytokine deficiencies.

Original languageEnglish (US)
Pages (from-to)404-412
Number of pages9
JournalJournal of the European Academy of Dermatology and Venereology
Volume30
Issue number3
DOIs
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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